Derived Variables from CARDIA Data

 

Conditions

Definition

SAS Code

Asthma: Current Asthma

Years 0 and 2: Ever had doctor confirmed asthma or still having asthma or on asthma medications.

Year 5: On asthma medications

Other Years: Ever had asthma or had asthma in last year or on asthma medications.

Asthma_Current

Asthma: Lifetime Asthma

If current asthma at any year the lifetime asthma whole life

Asthma_Lifetime

Blood Pressure: Elevated Blood  Pressure

SBP>=130 mmHg or DBP>=85 mmHg or on hypertensive medications (including hypertension).

BloodPressure_Elevated

Blood Pressure: Hypertension

SBP>=140 mmHg or DBP>=90 mmHg or on hypertensive medications.

BloodPressure_Hypertension

Cardiovascular Health Index

Adapted from the American Heart Association recommendations http://circ.ahajournals.org/content/121/4/586

cvhindex.sas

Cognitive Function Scores

CARDIA Cognitive Function Scores.PDF

CognitiveFunctionScores

Depression: Depression

Depression score>=16.

Depression

Depression: Clinical Depression

Depression score>=21.

Depression_Clinic

Diabetes

Report before May 2011: Fasting glucose>=126 mg/DL or on diabetic medications but not pregnant   
May 2011 report: Fasting glucose>=126 mg/DL or 2 hour glucose tolerance test>=200 mg/DL or hemoglobin HbA1c>=6.5% or on diabetic medications but not pregnant.

Diabetes

Framingham Coronary Heart Disease (10-year risk)

http://www.framinghamheartstudy.org/risk-functions/coronary-heart-disease/index.php

Wilson, D'Agostino, Levy et al. 'Prediction of Coronary Heart Disease using Risk Factor Categories', Circulation 1998.

FraminghamScores

Glomerular filtration rate (GFR)

DRD: Levey AS, Greene T, Kusek JW, et al. A simplified equation to predict

glomerular filtration rate from serum creatinine (Abstr). J Am Soc Nephrol 11:155A, 2000.   

EKD_EPI: Levey AS, Stevens LA, Schmid CH, et al. A New Equation to

Estimate Glomerular Filtration Rate. Ann Intern Med 150:604-612, 2009.

GFR

HOMA

Matthews HOMA Paper Diabetologia 1985.PDF

Matthews DR et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in men. Diabetologia 28:412-419, 1985.

HOMA

Hyperinsulinemia

Insulin>=20 microU/ML.

Hyperinsulinemia

Lipid: Dyslipidemia

Triglycerides>=150 mg/DL or HDL<35 mg/DL for male  
Triglycerides>=150 mg/DL or HDL<45 mg/DL for female.

Lipid_Dyslipidemia

Lipid: High Cholesterol

Cholesterol>=240 mg/DL.

Lipid_HighCholesterol

Lipid: High Triglycerides

Triglycerides>=200 mg/DL.

Lipid_HighGlycerides

Lipid: High LDL

LDL>=160 mg/DL.

Lipid_HighLDL

Lipid: Low HDL

HDL<35 mg/DL for male.

HDL<45 mg/DL for female.

Lipid_LowHDL

Marijuana: MarijuanaYears

Lifetime marijuana use in marijuana-years of exposure

MarijuanaLifetime

Metabolic Syndrome

Meet 3 out of these 5 criteria:    
1. Waist girth>=102 cm for male or >=88 cm for female;
2. Triglycerides>=150 mg/DL;
3. HDL<40 mg/DL for male or<50 mg/DL for female; 
4. SBP>=130  mmHg or DBP>=85 mmHg or on hypertensive medications; 
5. Fasting glucose>=110 mg/DL.

MetabolicSyndr

Body Weight: Obesity

BMI>=30 if not pregnant.

Obesity

Body Weight: Over Weight

25<=BMI<30 if not pregnant.

OverWeight

Apthobiological Determinants of atherosclerosis in youth (PDAY) risk score

Gidding SS et al. Prediction of coronary artery calcium in young adults using the apthobiological determinants of atherosclerosis in youth (PDAY) risk score. Arch Intern Med 166:2341-2347, 2006.

PDAY

Physical Activity: Heavy Intensity Score

CARDIA_PhysicalActivit.PDF

PhysicalActivity_Heavy

Physical Activity: Moderate Intensity Score

CARDIA_PhysicalActivit.PDF

PhysicalActivity_Moderate

Physical Activity: Total Intensity Score

CARDIA_PhysicalActivit.PDF

PhysicalActivity_Total

Pregnancy

CARDIA derived variables created by Dr. Erica Gunderson. Variables available upon request. Please read documentation for more details.

CARDIA Pregnancy
Derived Variables
Y0 to Y30 May 11, 2018

Pulmonary Function

Hankinson Spirometric reference values.PDF

Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 159:179–187, 1999.

PulmonaryFunc

Reynolds Risk Score

Reynolds Risk Score Ref.PDF

Ridker PM et al. Development and validation of improved algorithms for

the assessment of global cardiovascular risk in women. JAMMA 297:611-619, 2007.

ReynoldsRiskScore

Smoking: Pack Years

Accumulated packyears assuming continuous smoking among exam years.

SmokingPackYears

Smoking: Pack Years by Dr. Mark Pletcher

Dr Mark Pletcher Packyears Algorithms.PDF

SmokingPackYears_MP

Smoking: Smoking Status

0=Never smokers; 1=Former smokers; 2=Current smokers.

SmokingStatus